Publications

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• Spence J.P.+,#, Mostafavi H.+,#, et al., Specificity, length and luck drive gene rankings in association studies. Nature (2025).

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• Mostafavi H. Making sense of the polygenicity of complex traits. Nature Reviews Genetics 1-1 (2025).

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• Lee S., Mostafavi H. Missing regulatory effects on complex traits: Contribution of distal variants. Cell Genomics 5.3 (2025).

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• Simons Y., Mostafavi H., Smith C.J., Pritchard J.K., Sella G. Simple scaling laws control the genetic architectures of human complex traits. PLoS Biol. 23, e3003402 (2025).

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• Samuel P.S., Olivia S., Mostafavi H. et al., A litmus test for confounding in polygenic scores. bioRxiv (2025).

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• Zeng T., Spence J.P., Mostafavi H., Pritchard J.K. Bayesian estimation of gene constraint from an evolutionary model with gene features. Nat. Genet. 56, 1632-1643 (2024).​

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• Patel R., Weiß C.L., Zhu H., Mostafavi H. et al., Characterizing selection on complex traits through conditional frequency spectra. Genetics, iyae210 (2024).

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• Mostafavi H.#, Spence J.P., Naqvi S., Pritchard J.K.# Systematic differences in discovery of genetic effects on gene expression and complex traits. Nat. Genet. 55, 1866-1875 (2023). Featured in Nat. Genet. News & Views and Nat. Methods Research Highlight.

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• Spence J.P., Zeng T., Mostafavi H., Pritchard J.K. Scaling the Discrete-time Wright Fisher model to biobank-scale datasets. Genetics 225, iyad168 (2023).​​

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• Patel R., Musharoff S.A., Spence J.P., Pimentel H., Tcheandjieu C., Mostafavi H. et al., Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits. Am. J. Hum. Genet. 109, 1-12 (2022).  

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• Venkataraman G.R., DeBoever C., Tanigawa Y., Aguirre M., Ioannidis A.G., Mostafavi H. et al., Bayesian model comparison for rare-variant association studies. Am. J. Hum. Genet. 108, 2354-2367 (2021).  

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• Mostafavi H.+,#, Harpak A.+,#, Conley D., Pritchard J.K., Przeworski M.# Variable prediction accuracy of polygenic scores within an ancestry group. eLife 9, e48376 (2020). 

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• Berg J.J., Harpak A., Sinnott-Armstrong N., Jorgensen A.M., Mostafavi H. et al., Reduced signal for polygenic adaptation of height in UK Biobank. eLife 8, e39725 (2019). 

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• Fuller Z., Berg J.J., Mostafavi H., Sella G., Przeworski M. Measuring intolerance to mutation in human genetics. Nat. Genet. 51, 772-776 (2019).

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• Mostafavi H.#, Berisa T., Day F., Perry J., Przeworski M.+,#, Pickrell J.K.+,# Identifying genetic variants that affect viability in large cohorts. PLoS Biol. 15, e2002458 (2017). Accompanied by a summary in The Conversation.

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• Mostafavi H.+, Thiyagarajan S.+, Stratton B.S., Warner J.M., Karatekin E., Rothman J.E.#, O'Shaughnessy B.# Entropic forces drive self-organization and membrane fusion by SNARE proteins. PNAS 114, 5455-5460 (2017). 

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• Moyassari A., Mostafavi H., Gkourmpis T., Hedenqvist M., Gedde U.W., Nilsson F. Simulation of semi-crystalline polyethylene: Effect of short-chain branching on tie chains and entanglements. Polymer 72, 177-184 (2015).